David and Lisa (1962) is a low-budget film directed by Frank Perry, often cited as one of his best works. Based on the novel by Theodore Isaac Rubin, the screenplay, written by Frank Perry’s wife Eleanor, tells the story of a bright young man suffering from a severe case of obsessive-compulsive disorder (OCD). This lands him in a residential treatment center, in which he meets a girl with dissociative identity disorder (formerly known as multiple personality disorder, and often mistakenly called “schizophrenia“) called Lisa, whom he learns to understand.

The film is shot entirely in black-and-white, and it runs for 93 minutes. Shooting it cost US$183,000, and it made over US$1,000,000 in rentals on its first week.

David and Lisa earned Frank Perry a nomination for the 1962 Academy Award for Directing and Eleanor Perry for her Screenplay.

David and Lisa is also the title of the stage play (c. 1967) with the same basic characters and story, and it is the title of a 1998 made-for-TV film starring Lukas Haas, Sidney Poitier, and Brittany Murphy.

• David Clemens – David is a young man played by Keir Dullea who suffers from Aphenphosmphobia. He cannot stand to be touched by others. He is cold and chooses to be isolated from his peers. He has an obsession with time.
• Lisa Brandt – Lisa is a young woman played by Janet Margolin. She suffers from a split personality. When she is Lisa, she can only speak in rhymes. When she is Muriel, she cannot speak, but only write.
• Dr. Swinford – The doctor at the treatment center played by Howard Da Silva. He is an older, pensive man who manages to break through David’s tough exterior.

The film starts as David Clemens (Keir Dullea) is brought to a residential treatment center by his apparently caring mother. He becomes very upset when one of the inmates brushes his hand, as he believes touches can kill him. Cold and distant, he mainly concentrates on his studies, especially that of clocks, which he appears to be obsessed with. We later learn that he has a recurring dream in which he murders people by means of a giant clock.

He meets Lisa Brandt (Janet Margolin), a girl who has two personalities: one of them, Lisa, can only speak in rhymes, while the other, Muriel, cannot speak, but only write. David befriends her by talking to her in rhymes. Following an argument with his mother when she comes to visit him, his parents decide he should leave the place. After staying at their house for a short time, David runs away and goes back to the residential treatment center, where he is allowed to stay. He has a small argument with Lisa, and she takes the train to the city, unnoticed by anyone.

In the final scene, David, who realizes she would go back to a museum in which she had embraced a statue before, finds her. Lisa appears to be cured and doesn’t need to rhyme anymore, and David allows her to hold his hand on the way back.